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. 1998 Sep;5(4):274–288.

Figure 3.

Figure 3

Fear conditioning studies demonstrate gene dosage-dependent LTM deficits in CREB mutant mice. (A) In the 24-hr version of the test, one-way ANOVAs exhibit a significant difference between the five groups investigated in both contextual (dark-shaded bars) and cued (light-shaded bars) form of the test [context: F(4,69) = 20.57, P < 0.001; cued: F(4,69) = 20.17, P < 0.001]. C57BL/6xFVB/N F1 hybrid wild types perform significantly worse than C57BL/6 or C57BL/6x129Svev wild types. Compared with their F1 hybrid wild-type littermates, CREBαΔ mice show mild but statistically not significant deficits. CREB- comp mice demonstrate severe and statistically highly significant deficits compared with their wild-type littermates (context and cued P < 0.001, respectively). (B) In the 0.5-hr version of the test, one-way ANOVAs do not exhibit significant differences between the three groups (context: F(2,33) = 0.344, P = 0.71; cued: F(2,33) = 0.287, P = 0.75).