Figure 4.

Open-field activity in RTH transgenic mice [(♦) n = 6 female; n = 4 male] and wild-type controls [(○) n = 7 female; n = 5 male] after 24 hr of food restriction. Horizontal and vertical beam breaks were tallied every 5 min for 90 min. (A) Horizontal activity of female mice; (B) horizontal activity of male mice; (C) vertical activity of female mice; (D) vertical activity of male mice. After the first 10 min, food-restricted male transgenic mice were significantly less active than male controls, on both horizontal and vertical activity. Data are presented as mean ± s.e.m.