Table 1.

Comparison of site entropies and solvent accessibility

	Residue	Site entropy	% exposed*
Subtilisin E	9	2.55	56
	14	2.50	34
	76	2.45	46
	107	1.62	1
	118	2.37	79
	131	2.43	37
	156	2.19	53
	161	2.69	92
	166	0.96	8
	181	0.36	23
	182	1.81	52
	188	2.50	88
	194	2.59	71
	206	1.94	40
	218	2.54	50
	255	2.54	41
T4 lysozyme	14	2.59	47
	16	2.02	53
	22	1.66	19
	26	1.03	2
	40	2.54	80
	41	1.91	34
	93	2.52	81
	113	2.54	69
	116	2.50	51
	119	2.11	54
	147	2.10	50
	151	1.53	17
	153	0.55	0
	163	2.49	63

^*The percent surface area of the side chain accessible by solvent. The surface areas were calculated using the Lee and Richards definition of solvent accessible surface area using 1.4 Å as the radius of water (41). The average solvent accessibility is 24% and the standard deviation is 26%.