Figure 3.

Comparison of glutamate receptor antagonists shows NR2B dependence of BDNF effect. (A) Magnitude of glutamate-activated current after 20–25 min of exposure to BDNF. AP-5 and ifenprodil reduced the response to similar levels. (*) P < 0.005 vs. BDNF alone. (B) Percent block of the glutamate-activated current either prior to, or 25 min following application of BDNF. The far greater block by AP-5 after exposure to BDNF further demonstrates that it is NMDA receptor activity that is upregulated by BDNF. (**) P < 0.001 vs. Pre-BDNF.