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. 1999 Sep;6(5):467–477. doi: 10.1101/lm.6.5.467

Figure 2.

Figure 2

Figure 2

Figure 2

D-AP5 inhibits primed LTD but not priming itself in mature slices from 50- to 65-day-old mice. (A) Sample fEPSPs recorded before (1) and 30 min after the LFS (2) from unprimed, HFS-primed, and D-AP5-treated (during LFS) primed slices. Calibration bars, 2 mV, 10 msec. (B) Facilitation of LTD induction by prior HFS. Each arrow represents three high-frequency trains (100 Hz, 1 sec) at 20-sec intervals. The control group received no priming trains. (C) Attenuation of primed LTD by D-AP5 when applied during the LFS. D-AP5 was applied during the HFS only (control group) or throughout the experiments (D-AP5 group). Both groups received the priming trains and subsequent LFS. n = 5–8 for each group.