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. 1999 Sep;6(5):467–477. doi: 10.1101/lm.6.5.467

Figure 4.

Figure 4

Figure 4

OFQ inhibits NMDA receptor-dependent depotentiation. (A) The time course for multiple HFS-induced long-lasting LTP, reversal of the LTP by a LFS, and the effect of OFQ on depotentiaiton. The same HFS protocol as used for priming was applied in the absence of D-AP5 to induce LTP. The LFS was the same as used in LTD experiments. (B) Summary of depotentiation experiments. The predepotentiation level represents the LTP measured 30 min after the last HFS in all groups (solid bars). The depotentiation was quantified 30 min after the completion of LFS (stippled bars). For the LTP group that received no LFS, the remaining LTP at 85 min after the HFS (stippled bars) was used for comparison with other groups. n = 4–7 for each group. (*) P < 0.01 as compared with the LTP group. ( ) P < 0.01 as compared with the depotentiation group.