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. 2011 Jun 8;5:32. doi: 10.3389/fnsys.2011.00032

Figure 2.

Figure 2

Non-locomotor behaviors in line 6 Drd1a-tdTomato/C57Bl/6 and Drd2-EGFP/C57Bl/6 transgenic mice. Time course plots of the number of vertical movements basally and following acute cocaine injection (20 mg/kg i.p.) demonstrate that transgene-positive mice are similar to transgene-negative littermate control mice in (A) Drd1a-tdTomato line 6 mice (Drd1a-tdTomato+/−, red, n = 14; Drd1a-tdTomato−/−, black, n = 15; p = 0.778) and (B) Drd2-EGFP mice (Drd2-EGFP+/−, green, n = 17; Drd2-EGFP−/−, black, n = 15; p = 0.256). No differences in stereotypic movements basally and following acute cocaine injection were observed between transgene-positive and transgene-negative littermate control mice in (C) Drd1a-tdTomato line 6 mice (Drd1a-tdTomato+/−, red, n = 14; Drd1a-tdTomato−/−, black, n = 15; p = 0.615) and (D) Drd2-EGFP mice (Drd2-EGFP+/−, green, n = 17; Drd2-EGFP−/−, black, n = 15; p = 0.411). (E) Drd1a–tdTomato line 6 mice and transgene-negative littermate control mice spend a similar amount of time in center region of open field test chamber (Drd1a-tdTomato+/−, red, n = 14; Drd1a-tdTomato−/−, black, n = 15; p = 0.647). (F) Drd2-EGFP+/− (green, n = 17) spend significantly less time in the center region of the open field chamber compared to Drd2-EGFP−/− littermates (black, n = 15; p = 0.013).