Figure 4.

(A,B) Effects of anisomycin on retention of one trial step-down inhibitory avoidance task in rats preexposed to the task apparatus (foot shock intensity, 0.4 ma; training-test interval, 24 hr). Retention of step-down inhibitory avoidance is expressed as median (interquartile range) session latencies (in seconds). Animals received bilateral 0.8μl infusions of vehicle (□) or anisomycin (▪; 80 μg) in the dorsal hippocampus 15 min before (A) or 3 hr after (B) training session. n = 10–13 animals per group. (*) Significant difference when compared with control group (Mann–Whitney U test, P < 0.01). All groups, except anisomycin −15 min, showed significant training-test differences (Wilcoxon test, P < 0.01).