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. 2011 May 17;2:318. doi: 10.1038/ncomms1317

Figure 1. Phenotype of endothelial-specific IKKβ knockout mice.

Figure 1

(a) Photograph of littermate wild type ('control') and IKKβΔEC ('ΔIKKβ') mice and body weight±s.d. shown from mice of each genotype at the indicated age (n=3/each group, *P<0.005 in repeated two-way ANOVA). (b) H&E staining of embryos at E14. Scale bars: 1 mm. (c) Staining of placentae by H&E and immunohistochemistry for von Willebrand Factor at E14. Scale bars: 10 μm. (d) Placenta weight from mice of each genotype (n=6 in IKKβΔEC and n=3 in control mice, *P<0.05 in two-sided Student's t-test. Error bars:±s.d.). (e) Confocal microscopy images of vascular endothelium in IKKβΔEC and control mice immunostained with antibody for CD146 and IKKβ. Scale bars: 100 μm.