Table 3.

Physical and Transport Parameters

Parameter	Value	Ref.
Radius of domain, R	50 μm	Assumed
Half-Length of domain, L	80 μm	Assumed
Length of tip cell, Lcell	40 μm	[12]
Radius of sprout, Rsprout	2 μm	[12]
	Tip cell surface area: 515 μm2	calculated
Diffusivities, D114, D121, D165, D189	68.6 μm2/s (see Methods)	estimated
Local Available Volume Fraction of the extracellular matrix, KECM	0.85	[57]