Figure 1.

Genome-Wide-Association Results from the Initial GWAS

(A) Quantile-quantile plots of the observed p values (–log₁₀P) for association.

(B) The genome-wide distribution of –log₁₀ p values from the unadjusted Cochran-Armitage trend test is shown across the chromosomes. Values that take into account genetic matching and correction for the inflation factor of 1.07 are shown for 493,947 SNPs that were of sufficient quality, after quality-control filtering, in 419 unrelated Han Chinese patients with high myopia and in 699 unrelated Han Chinese controls. Each chromosome is depicted in a different color. –log₁₀(UNADJ) refers to −log₁₀ p value of the Cochran-Armitage trend test unadjusted by multiple testing. The dotted line indicates the genome-wide threshold for further follow-up studies (p < 1.0 × 10⁻⁴).