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. 2011 Jun 10;88(6):827–838. doi: 10.1016/j.ajhg.2011.05.008

Figure 2.

Figure 2

Pedigrees and Linkage Intervals for arCC Families

(A) Twelve arCC pedigrees collected from Pakistan. Filled symbols denote affected individuals. Eight pedigrees (060003, 060012, 060041, 060058, 060064, 060069, 060091, and 060094) were used for genome-wide linkage scans and fine mapping of arCC intervals and candidate-gene mutation screenings. Four pedigrees (060014, 060031, 060044, and 060054) were used for fine mapping of arCC intervals and candidate-gene mutation screenings. Individuals who were genotyped are marked with an asterisk.

(B) Refined arCC interval on the basis of haplotype analysis of patients with recombination events. Markers with the homozygous genotype are boxed so that the region without recombination is defined. Alleles for markers D3S3685 and D3S1289 in patients with recombination events are in bold so that the telomeric and centromeric breakpoints, respectively, are shown. The disease interval was placed between markers D3S3685 and D3S1289.