Figure 4.

FYCO1 Domain Structure and Mutations

(A) Schematic diagram of FYCO1, showing the locations and effects of the recessive mutations. Domain structure of FYCO1. FYVE represents the FYVE zinc-finger domain; LIR represents the LC3-interacting region; and GOLD represents the Golgi dynamics domain. Red arrows show the positions of the truncation mutations associated with arCC, and the blue arrow shows the missense mutation p.Leu1376Pro.

(B) Amino acid sequence alignment around the FYCO1 Leu1376 amino acid (asterisk) in eight species, ranging from humans to zebrafish.