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. 2010 Jun;11(6):530–542. doi: 10.1016/S1470-2045(10)70095-4

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Odds ratios (OR) for breast cancer associated with IGF1 concentration, according to menopausal status at blood collection and other factors

The OR is the estimate of the linear trend obtained by replacing the categorical variables representing the fifths of IGF1 concentration in controls by a continuous variable scored as 0, 0·25, 0·5, 0·75 and 1. Black squares indicate the OR and the horizontal lines show the 95% CIs. The area of each square is proportional to the amount of statistical information (inverse of the variance of the logarithm of the OR). The vertical dotted line indicates the OR for all studies. Tests for heterogeneity are for the difference in the association of IGF1 with breast-cancer risk between subgroups. Estimates are from conditional logistic regression on case-control sets matched within each study. HRT=Hormone replacement therapy.