Table 2.
Differential gene expression in brains of VEEV infected ICAM-1 WT mice (n = 3) as compared to IKO mice (n = 3) at 96 hr pi.
| Position | RefSeq Number | Symbol | Description | IKO Mean±SEM | WT Mean±SEM |
Fold Change (IKO/WT) |
|---|---|---|---|---|---|---|
| 7 | NM_011332 | Ccl17 | Chemokine (C-C motif) ligand 17 (Ccl17) | 73.57 | (A) | P-IKO |
| 13 | NM_019577 | Ccl24 | Chemokine (C-C motif) ligand 24 (Ccl24) | (A) | 273.69 POR | P-WT |
| 22 | NM_009912 | Ccr1 | Chemokine (C-C motif) receptor 1 (Ccr1) | 132.24 ± (40.75) | 28.80 POR | 4.59 |
| 35 | NM_019494 | Cxcl11 | Chemokine (C-X-C motif) ligand 11 (Cxcl11) | 435.04 ± (167.36) | 690.98 ± (322.64) | 0.63 |
| 37 | NM_018866 | Cxcl13 | Chemokine (C-X-C motif) ligand 13 (Cxcl13) | 163.29 POR | 245.09 ± (156.61) PTwR | 0.67 |
| 49 | NM_008337 | Ifng | Interferon gamma (Ifng) | 211.35 ± (21.67) PTwR | 122.81 ± (12.68) PTwR | 1.72 |
| 51 | NM_010548 | Il10 | Interleukin 10 (Il10) | (A) | 57.40 ± (43.51) PTwR | P-WT |
| 68 | NM_008362 | Il1r1 | Interleukin 1 receptor, type I (Il1r1) | 119.93 POR | (A) | P-IKO |
| 69 | NM_010555 | Il1r2 | Interleukin 1 receptor, type II (Il1r2) | 287.27 POR | 172.19 ± (94.76) PTwR | 1.67 |
| 73 | NM_016971 | Il22 | Interleukin 22 (Il22) | (A) | 186.84 POR | P-WT |
| 74 | NM_008368 | Il2rb | Interleukin 2 receptor, beta chain (Il2rb) | 151.12 POR | 31.83 POR | 4.75 |
| 93 | NM_011101 | Prkca | Protein kinase C, alpha (Prkca) | 60.8 POR | (A) | P-IKO |
| 94 | NM_009007 | Rac1 | RAS-related C3 botulinum substrate 1 (Rac1) | 195.79 ± (6.81) PTwR | 105.57 ± (81.61) PTwR | 1.85 |
| 95 | NM_007926 | Scye1 | Small inducible cytokine subfamily E, member 1 (Scye1) | 385.53 ± (137.18) | 243.61 ± (159.47) | 1.58 |
| 96 | NM_009263 | Spp1 | Secreted phosphoprotein 1 (Spp1) | 693.01 ± (74.26) | 389.60 ± (127.58) | 1.78 |
| 104 | NM_133211 | Tlr7 | Toll-like receptor 7 (Tlr7) | 176.40 ± (87.47) PTwR | 35.74 ± (22.32) PTwR | 4.94 |
| 107 | NM_013693 | Tnf | Tumor necrosis factor (Tnf) | 74.90 ± (8.85) PTwR | 193.78 POR | 0.39 |
| 112 | NM_008510 | Xcl1 | Chemokine (C motif) ligand 1 (Xcl1) | 76.09 ± (42.81) PTwR | (A) | P-IKO |
Average expression values of gene are given. Where gene expression was detected in only one biological sample and not the replicates, the gene expression value is followed by POR (present in one replicate), similarly where the gene expression was detected in two biological replicates the gene expression value is followed by PTwR (present in two replicates). The fold expression values are derived by dividing average expression (or expression value from one or two replicates) of VEEV infected IKO samples with average expression (or expression value from one replicate) of VEEV infected ICAM WT samples and vice versa. PI = Expressed only in VEEV infected samples, PC = Expressed in uninfected saline control samples only, (A) = absent. Values are expressed as ± SEM.