Table 1.
Baseline data and key results for the IVGTT and the glucose clamp.
| Parameter | Mean (SD), or median (25th-75th percentiles) |
Unit |
|---|---|---|
| Health status | ||
| Body mass index | 23.4 (2.3) | kg/m2 |
| HbA1c | 44 (0.5) | mmol/mol |
| Blood Hb concentration | 126 (14) | mmol/L; |
| Serum creatinine concentration | 83 (3) | μmol/L |
| Serum sodium and potassium concentrations | 141 (2); 3.9 (0.3) | mmol/L |
| IVGTT | ||
| Plasma glucose, baseline | 4.8 (0.5) | mmol L-1 |
| Plasma insulin, baseline | 21 (12-24) | pmol L-1 |
| Volume of distribution (Vd) | 14.0 (6.5) |
L |
| per kg body weight | 0.20 (0.09) | L kg-1 |
| Clearance (CL) | 0.63 (0.26) |
L min-1 |
| per kilo body weight | 9.3 (3.8) | ml min-1 kg-1 |
| Insulin sensitivity (SI) of MINMOD | 16 (7-32) | 10-5 L pmol-1 min-1 |
| Glucose effectiveness (SG) in MINMOD | 13 (5-26) | 10-3 min-1 |
| Glucose clamp | ||
| Plasma glucose, baseline | 5.0 (1.0) | mmol L-1 |
| Plasma insulin, baseline | 16 (7-30) | pmol L-1 |
| Plasma glucose, mean 90-120 min | 5.7 (0.3) | mmol L-1 |
| Plasma insulin, mean 90-120 min | 167 (34) | pmol L-1 |
| Glucose metabolism, M, 90-120 min | 3.1 (1.2) | mmol min-1 |
| Mbw = per kg body weight | 45 (15) | μmol min-1 kg-1 |
IVGTT = intravenous glucose tolerance test