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Time-course of the changes induced by MDMA (12.5 mg/kg, i.p.) on IL-1ra (endogenous antagonist of IL-1 receptor) levels in a) frontal cortex and b) hypothalamus. IL-1ra levels were measured 1 h, 3 h and 6 h after drug injection. Results shown as mean ± SEM (n = 6-8). Different from saline: ***p < 0.001. Different from MDMA-treated group at 1 h: fffp < 0.001.
