Figure 1.

SEC weight distributions of mouse-liver glycogen from various individual adult healthy (db/+, blue, A; +/+, green, B) and adult type 2 diabetic/obese (db/db, red, C) mice and from various individual young db/db mice (which would later have become diabetic; red) and young db/+ mice (which would not have become diabetic later; blue) mouse-liver glycogen (D). The normalization of these distributions is arbitrary and for convenience is chosen so that their areas are unity. Identification of individual mice are given in the Supporting Information. Inserted in part A is a transmission electron micrograph of mouse liver glycogen showing α and β particles. The diameter of the α particle in the micrograph is ∼150 nm.