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. Author manuscript; available in PMC: 2011 Jun 13.
Published in final edited form as: Epigenetics. 2008 May 9;3(3):134–142. doi: 10.4161/epi.3.3.6252

Figure 2.

Figure 2

Histopathological analysis of erythroleukemia and lymphoma in fetal liver cell transplanted mice. (a) Normal Spleen from mice receiving Lsh+/+ fetal liver cells. Lymphoid tissue in white pulp (wp) and normal extramedullary hematopoiesis in red pulp (rp) (H&E 20× objective). (b) Spleen with erythroleukemia from mice transplanted with Lsh−/− fetal liver cells. Effacement of white pulp by expansion of erythropoiesis originating in the red pulp. This hematopoietic neoplasm occurred in mice transplanted with Lsh−/− and Lsh−/− p53−/− fetal liver cells (H&E, 20× objective). (c) Spleen with erythroleukemia from mice transplanted with Lsh−/− fetal liver cells. Many erythrocyte precursors (cells with prominent nucleoli) as well as numerous metarubricytes (dark nuclei) (H&E, 40× objective). (d) Liver erythroleukemia from mice transplanted with Lsh−/− fetal liver cells. Circulating metarubricytes in hepatic sinusoids can be seen (arrow) (H&E, 40× objective). (e) T cell lymphoma from mice transplanted with Lsh−/−p53−/− fetal liver cells (H&E, 20×, objective). (f) Thymus with sheets of lymphoblasts from mice transplanted with Lsh−/−p53−/− fetal liver cells. (H&E, 40× objective).