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5-HT–LTD is cAMP pathway dependent. A, Forskolin (10–20 μm) potentiated EPSC amplitude. B, CP 93129 (2 μm, 4 min) persistently depressed EPSC amplitude. Forskolin blocked CP 93129-induced LTD of EPSC amplitude, but transient EPSC depression was observed during agonist application. C, In the presence of 8-Br-cAMP (80 μm), CP 93129 did not depress EPSC amplitude. Calibration: 100 pA, 20 ms.
