Table 2.
The association of insulin sensitivity (glucose disposal rate) and cytokine-mediated inflammation: Multivariable linear regression
| hsC-reactive protein | lnterleukin-6 | |||
|---|---|---|---|---|
| β-coefficient (95% CI) | p-value | β-coefficient (95% CI) | p-value | |
| Whole sample (n=1052) | ||||
| Model A | -0.39 (-0.51-(-0.27)) | <0.001 | -0.28 (-0.40-(-0.15)) | <0.001 |
| Model B | -0.12 (-0.21-(-0.03)) | 0.01 | -0.11 (-0.21-(-0.02)) | 0.01 |
| Model C | -0.13 (-0.23-(-0.03) | 0.01 | -0.17 (-0.28-(-0.07) | <0.001 |
| Without diabetes (n=991) | ||||
| Model A | -0.37 (-0.49-(-0.25)) | <0.001 | -0.26 (-0.38-(-0.13)) | <0.001 |
| Model B | -0.13 (-0.22-(-0.04)) | 0.006 | -0.12 (-0.22-(-0.03)) | 0.01 |
| Model C | -0.13 (-0.23-(-0.03)) | 0.01 | -0.17 (-0.28-(-0.07)) | <0.001 |
| Without diabetes and without MetS (NCEP) (n = 824) | ||||
| Model A | -0.32 (-0.46-(-0.20)) | <0.001 | -0.22 (-0.35-(-0.09)) | <0.001 |
| Model B | -0.12 (-0.22-(-0.01)) | 0.03 | -0.13 (-0.23-(-0.02)) | 0.02 |
| Model C | -0.13 (-0.24-(-0.01)) | 0.03 | -0.17 (-0.29-(-0.06)) | 0.004 |
| Normal weight, without diabetes and without MetS | ||||
| (n=382) | ||||
| Model A | -0.28 (-0.45-(-0.12)) | <0.001 | -0.26 (-0.44-(-0.07)) | 0.007 |
| Model B | -0.18 (-0.33-(-0.04)) | 0.01 | -0.23 (-0.39-(-0.07)) | 0.005 |
| Model C | -0.20 (-0.36-(-0.03) | 0.02 | -0.30 (-0.48-(-0.11) | 0.002 |
Data are regression coefficients indicatingthe change in glucose disposal rate (mg/kg bw/min) associated with 1-standard deviation higher hsCRP or IL-6, respectively. Model A adjusted for age, Model B adjusted for the age and the components of the metabolic syndrome (systolic blood pressure, diastolic blood pressure, antihypertensive medication, HDL-cholesterol, triglycerides, lipid lowering treatment, fasting plasma glucose, waist circumference), Model C adjusted for age and lifestyle factors (Body mass index, leisure time physical activity and smoking). Number of participants in the analyses with IL-6: whole sample n=968, without diabetes n = 913, without diabetes and without MetS n = 755, Normal weight, without diabetes and without MetS (n=352): Metabolic syndrome (MetS) was defined usingthe ATP lll-NCEP-definition.