Table 2.
Mean pre-menarche serum hormones and SHBG concentrations in DISC girls according to (a) birth weight (n = 278) (b) birth weight, adjusted for years until menarche (n = 278)
| n samples (max samples per individual) | Lower birth weight (≤2,892 g) Mean (95% CI) | Average birth weight (2,920–3,884 g) Mean (95% CI) | Higher birth weight (≥3,912 g) Mean (95% CI) | p value | |
|---|---|---|---|---|---|
| (a) | |||||
| Estradiol, ng/dl† | 451 | 1.91 (1.41, 2.60)a,b | 1.42 (1.13, 1.77)a | 1.38 (1.01, 1.90)b | 0.041 |
| 5 | 0.022 | ||||
| Non-SHBG-bound estradiol, ng/dl† | 388 | 0.98 (0.65, 1.49)a,b | 0.73 (0.53, 1.01)a | 0.64 (0.42, 0.97)b | 0.051 |
| 4 | < 0.012 | ||||
| Estrone, ng/dl† | 451 | 1.71 (1.40, 2.09) | 1.58 (1.37, 1.82) | 1.58 (1.29, 1.93) | 0.591 |
| 5 | 0.262 | ||||
| Estrone sulfate, ng/dl† | 355 | 49.60 (38.17, 64.45) | 42.52 (34.91, 51.80) | 40.91 (31.42, 53.27) | 0.231 |
| 4 | 0.042 | ||||
| Androstenedione, ng/dl† | 444 | 67.10 (54.88, 82.05) | 57.37 (49.83, 66.06) | 55.11 (44.74, 67.89) | 0.131 |
| 5 | 0.012 | ||||
| Testosterone, ng/dl† | 381 | 15.44 (11.02, 21.64) | 13.73 (10.55, 17.87) | 13.06 (9.26, 18.43) | 0.621 |
| 4 | 0.052 | ||||
| DHEAS, ng/dl† | 453 | 47.12 (36.68, 53.35) | 43.77 (37.04, 45.82) | 40.84 (31.46, 51.55) | 0.521 |
| 5 | < 0.052 | ||||
| SHBG, nmol/dl† | 453 | 91.55 (74.64, 112.29) | 90.77 (79.16, 104.07) | 105.35 (85.14, 130.36) | 0.281 |
| 4 | 0.422 | ||||
| (b) | |||||
| Estradiol, ng/dl‡ | 451 | 1.69 (1.30, 2.19) | 1.39 (1.15, 1.69) | 1.50 (1.15, 1.96) | 0.161 |
| 5 | 0.242 | ||||
| Non-SHBG-bound estradiol, ng/dl‡ | 388 | 0.85 (0.70, 1.04) | 0.67 (0.64, 0.76) | 0.73 (0.60, 0.90) | 0.201 |
| 4 | 0.102 | ||||
| Estrone, ng/dl‡ | 451 | 1.62 (1.36, 1.93) | 1.59 (1.40, 1.80) | 1.68 (1.41, 2.01) | 0.711 |
| 5 | 0.972 | ||||
| Estrone sulfate, ng/dl‡ | 355 | 42.50 (33.85, 53.35) | 38.59 (32.50, 45.82) | 41.07 (32.71, 51.55) | 0.421 |
| 4 | 0.342 | ||||
| Androstenedione, ng/dl‡ | 444 | 59.20 (49.49, 70.82) | 53.63 (47.28, 60.84) | 55.71 (46.36, 66.94) | 0.381 |
| 5 | 0.152 | ||||
| Testosterone, ng/dl‡ | 381 | 13.02 (9.70, 17.47) | 12.55 (9.97, 15.78) | 13.14 (9.76, 17.70) | 0.861 |
| 4 | 0.322 | ||||
| DHEAS, ng/dl‡ | 453 | 42.41 (33.23, 54.14) | 40.91 (34.74, 48.16) | 41.01 (31.93, 52.68) | 0.941 |
| 5 | 0.202 | ||||
| SHBG, nmol/dl‡ | 453 | 96.80 (78.92, 118.72) | 94.13 (82.08, 107.94) | 105.28 (85.37, 129.83) | 0.481 |
| 4 | 0.742 | ||||
SD standard deviation, CI Confidence interval, SHBG sex hormone–binding globulin, DHEAS dehydroepiandrostenedione sulfate
a,b
Items in the same row marked with the same letter differ at p ≤ 0.05
1
p value for categorical birth weight;
2
p value for continuous birth weight
†
Geometric means and 95% CI adjusted for years until menarche, visit number, treatment group, and age
‡
Geometric means and 95% CI adjusted for years until menarche, visit number, treatment group, age, and years until menarche