TABLE 2.
Patient demographics including medical conditions, pre-operative labs, baseline parameters and intraoperative parameters.
| Parameter n=total incidence | ACEI (n=70) | CCB (n=80) | ARB (n=28) | BB (n=100) | Diuretic (n=44) |
|---|---|---|---|---|---|
| Medical History | |||||
| Age (years) | 69.6 +/− 10.3 | 71.3 +/− 8.5 | 72.1 +/− 8.1 | 70.6 +/− 8.6 | 71.5 +/− 8.4 |
| BMI (kg/m2) | 27.3 +/− 4.5 | 27.0 +/− 4.1 | 26.5 +/− 2.7 | 27.3 +/− 4.2 | 27.6 +/− 4.0 |
| CAD (n=98) | 30 (43%) | 41 (51%)* (p=0.005) | 8 (29%) | 53 (53%)* (p<0.001) | 23 (52%) |
| CHF (n=9) | 1 (<1%) | 2 (<1%) | 2 (7%) | 4 (4%) | 3 (7%) |
| MI (n=65) | 24 (34%) | 25 (31%) | 4 (14%) | 31 (31%) | 12 (27%) |
| Afib (n=11) | 3 (4%) | 6 (7%) | 1 (4%) | 7 (7%) | 2 (5%) |
| COPD (n=42) | 9 (13%) | 17 (21%) | 2 (8%) | 15 (15%) | 6 (14%) |
| DM (n=50) | 20 (29%) | 16 (20%) | 4 (14%) | 18 (18%) | 10 (23%) |
| Smoker (n=98) | 26 (37%) | 32 (40%) | 10 (36%) | 40 (40%) | 21 (48%) |
| Prev CEA (n=31) | 6 (9%) | 11 (13%) | 2 (7%) | 17 (17%) | 3 (7%) |
| Prev Stroke (n=109) | 30 (43%) | 25 (31%) | 9 (32%) | 38 (38%) | 23 (52%) |
| Pre-operative labs | |||||
| Hematocrit (%) | 40.5 +/− 3.83 | 40.60 +/− 5.2 | 40.4 +/− 3.3 | 40.6 +/− 4.5 | 40.0 +/− 4.8 |
| Creatinine (mg/dL) | 1.15 +/− 0.32 | 1.13 +/− 0.44 | 1.05 +/− 0.32 | 1.18 +/− 0.36* (p=0.01) | 1.15 +/− 0.32 |
| BUN (mg/dL) | 20.2 +/− 7.4 | 20.4 +/− 8.7 | 20.7 +/− 8.1 | 21.8 +/− 8.4* (p=0.03) | 23.6 +/− 10.0* (p=0.02) |
| Baseline parameters | |||||
| SBP (mmHg) | 146.2 +/− 23.9 | 145.7 +/− 22.9 | 148.8 +/− 20.6 | 144.6 +/− 22.7 | 142.3 +/− 20.3 |
| DBP (mmHg) | 76.5 +/− 12.0 | 75.2 +/− 10.0 | 80.2 +/− 12.2 | 77.4 +/− 12.4 | 76.0 +/− 13.1 |
| Intraoperative parameters | |||||
| Surgical duration (mins) | 143 +/− 37 | 140 +/− 39 | 151 +/− 40 | 145 +/− 34 | 150 +/− 34 |
| Cross Clamp duration (mins) | 38 +/− 12 | 36 +/− 14 | 36 +/− 10 | 37 +/− 11 | 40 +/− 11 |
| Fluids (mL) | 1248 +/− 435 | 1268 +/− 484 | 1250 +/− 588 | 1146 +/− 441 | 1175 +/− 362 |
| Total ephedrine (mg) | 6.2 +/− 10.3 | 4.1 +/− 8.2 | 5.8 +/− 14.7 | 5.9 +/− 10.7 | 6.6 +/− 11.7 |
ACEI: angiotensin converting enzyme inhibitor, CCB: calcium channel blocker, ARB: angiotensin receptor blocker, BB: beta blocker, BMI: body mass index, CAD: coronary artery disease, CHF: congestive heart failure, MI: history of previous myocardial infarction, Afib: history of chronic atrial fibrillation, COPD: history of chronic obstructive pulmonary disease, DM: diabetes mellitus, Smoker: currently a smoker, Prev CEA: history of previous carotid endarterectomy, Prev Stroke: history of previous stroke, BUN: blood urea nitrogen, SBP: systolic blood pressure, DBP: diastolic blood pressure. P values compare prevalence of demographic in patients receiving antihypertensive group vs. those not on class.
p<0.05: Significant by Fisher exact test (categorical data) or Mann-Whitney-Wilcoxon test (continuous data).