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. Author manuscript; available in PMC: 2012 Jun 14.
Published in final edited form as: Biochemistry. 2011 May 17;50(23):5154–5162. doi: 10.1021/bi200147a

Figure 1.

Figure 1

(A) Schematic experimental system of SMFS. AFM tip and mica surface were functionalized by MAS/Aβ-40 and APS/PEG/Aβ-40, respectively. In the schematic, Aβs are shown as β-hairpin structures in dimeric form. (B) A representative force-distance curve measured at pH 5 with apparent loading rate (ALR) 4280 pN/s. (C) The histograms of the rupture force distribution measured at pH 5 at ALR 4000 pN/s, 12690 pN/s, 46210 pN/s, 65160 pN/s. The most probable rupture force (Fr) for each loading rate was ~88 pN, ~102 pN, ~143 pN, and ~177 pN, respectively, which were calculated by Gaussian fitting.