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. 2001 Jan;8(1):26–34. doi: 10.1101/lm.36301

Figure 3.

Figure 3

LTP in slices from enriched mice is attenuated by an inhibitor of PKA. (a) A specific inhibitor of PKA, Rp-cAMPS (100 μM), did not alter LTP in slices from control mice (control: open triangles, n = 13 mice, 13 slices; control + Rp-cAMPS: closed triangles, n = 9 mice, nine slices). (b) Rp-cAMPS attenuated LTP in slices from enriched mice (enriched: open circles, n = 11 mice, 13 slices; enriched + Rp-cAMPS: closed circles, n = 8 mice, eight slices). Sample fEPSP traces were recorded from enriched slices in the absence (open circle) and presence (closed circle) of Rp-cAMPS, just before and 1 h after LTP induction. (c) Summary histogram showing mean fEPSP slopes measured 45 min after LTP induction in control (C) and enriched slices (E) in the absence and presence of Rp-cAMPS (R). An asterisk indicates P < 0.05 for comparison with the enriched group (E).