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. 2011 Feb 14;39(11):4680–4690. doi: 10.1093/nar/gkq1303

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Sequence specificities of ZFAs constructed by modular assembly, as determined by PBM. ID for ZFA and results of assay for activity follow Ramirez et al. F1, F2 and F3 columns indicate the module numbers used for construction of the ZFA. The rank of the intended 9-mer target (out of all 131 072 possible 9-mers) is determined by E-score; ME and HK refer to the two array designs used. The last column shows the intended target (based on the modules used for assembly) compared to PBM results (the sequence motif shown is generated from the (up to) top 10 8-mers bound by the ZFA, as described in the main text).