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. 2011 Feb 22;39(11):4836–4850. doi: 10.1093/nar/gkq1333

Figure 7.

Figure 7.

Linear correlations between the experimentally measured KM values and either (A) the Gibbs free energy averaged over −10 to +10 position of the ODNs [Equation (3)] as calculated by the ACTIVITY software or (B) the KM values predicted by Equations (3), (8) and (9). Open circle and dashed line, learning set: (A) each strand of ds ODN1–ODN6 (r = –0.832, α <0.001); (B) ds ODN1–ODN6 and ODN13–ODN15 (r = 0.850, α <0.005). Closed circle and straight line, control set: (A) each strand of ds ODN7–ODN12 (r = −0.806, α <0.00025); (B) ds ODN7–ODN12 and ODN16–ODN21 (r = 0.862, α <0.0005). Dotted line, all data combined: (A) each strand of ds ODN1–ODN12 [r = −0.457, α <0.025; Equation (8)]; (B) ds ODN1–ODN21 (r = 0.806, α < 0.00001).