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. 2011 Feb 9;39(11):4756–4768. doi: 10.1093/nar/gkr038

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — 2′-O-ribose cap MTases change their specificity in the course of the evolution. A minimum evolution tree of homologs of known 2′-O-ribose mRNA cap MTases is shown. The RrmJ family of 2′-O-ribose MTases that act on rRNA (together with their close homologs Mrm2, Trm7 and SpbJ) was used as an outgroup. Branches comprising multiple sequences from the same taxon have been collapsed and are illustrated as triangles marked by the name of the taxon and an experimentally characterized representative. Bootstrap values for nodes are shown.