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. 2011 Apr 12;39(11):e75. doi: 10.1093/nar/gkr173

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Validation of the prediction model. (A) Results of the 10-fold cross-validation test of the model. Distribution of Pearson's correlation between predicted promoter activities and observed luciferase activities is shown. (B) Validation of the TFBSs using promoter disruptant mutants. In each panel, luciferase activities of the original promoter clones (white) and the disruptant mutant clones (gray) are shown. The three upper panels represent the cases in which all promoter clones confirmed the contribution of the predicted TFBS. The three lower panels represent the cases in which predicted changes in luciferase activity were not observed for the examined promoter clones (indicated by the asterisks). In the upper margin in each panel, the ID of the TF corresponding to the examined TFBS is shown. Error bars represent standard deviations calculated from triplicate experiments.