Fig. 9.

Enhanced α7 integrin expression improves diaphragm pathology in 4-week-old dy^W−/− mice. (A) Hematoxylin and eosin staining of diaphragm muscle from 4-week-old dy^W−/− mice exhibit variation in myofiber size, presence of CLN and fibrosis. By contrast, the dy^W−/−;itga7+ diaphragm shows reduced muscle pathology. Scale bar: 20 μm. (B) Cross-sectional myofiber area of the diaphragm muscle of 4-week-old animals shows that the dy^W−/− ;itga7+ mice have a myofiber cross-sectional area more similar to wild-type animals than that observed in dy^W−/− mice (see also supplementary material Fig. S1).