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. Author manuscript; available in PMC: 2012 Jun 9.
Published in final edited form as: Neuron. 2011 Jun 9;70(5):1005–1019. doi: 10.1016/j.neuron.2011.04.019

Figure 4. Limited contribution of myosin light chain kinase to PTP.

Figure 4

(A through B), Plots of normalized EPSC amplitude as a function of time before and after PTP-inducing tetanization (inverted triangles) in slices from wild-type (black) and double knockout (purple) animals. Incubation with the MLCK inhibitor ML9 (filled symbols) partially affected PTP. (C through D), Plots of cumulative EPSCs as a function of stimulus number in slices from wild-type (C) and double knockout (D) animals, incubated with ML9. Gray lines are linear fits to the last 15 points. (E through F), Plots of ratios (2nd train/1st train) for ΣEPSC0, f0, and the slope of the linear fits. Incubation with ML9 (filled bars) significantly decreased f0 in both wild-types (black) and double knockouts (purple). * p < 0.05.