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. Author manuscript; available in PMC: 2012 May 16.
Published in final edited form as: Chem Res Toxicol. 2011 Apr 14;24(5):651–662. doi: 10.1021/tx100355a

Figure 9. Global structural changes in SIRT3 upon 4-HNE adduction.

Figure 9

(A) Molecular surface of SIRT3 protein (colored by atom charge). (B) Molecular surface of SIRT3 protein with 4-HNE adducted at Cys280 (colored by atom charge). A comparison of the AceCS2-Kac peptide and NAD+ in the active site of (C) unadducted and (D) adducted SIRT3 illustrates subtle changes throughout the binding cleft, consequently impacting both substrate and NAD+ docking into their respective binding sites.