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. 2011 May 6;5:65. doi: 10.1186/1752-0509-5-65

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Copyright ©2011 Guest et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of genes identified in this study and two previous large-scale RNAi-based screens for cell cycle regulators. (A) Venn diagrams showing the overlap between hits identified in the current study and those identified by Bjorklund et al. in a genome-wide screen [60] and by Bettencourt-Dias et al. in a kinome-wide screen [61]. Only genes screened in common between each pair of screens being compared are included for this analysis. Only genes that displayed a flow cytometry phenotype in Bettencourt-Dias et al. were used. (B) Validation rates for genes that we analyzed with a second dsRNA. Also shown is the validation rate for genes annotated with Gene Ontology biological process (GO BP) "cell cycle" [62]. Validation rate was determined as the percentage of genes that were tested with a second dsRNA that showed a matching phenotype for both dsRNAs.