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. 2011 May 6;5:65. doi: 10.1186/1752-0509-5-65

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Copyright ©2011 Guest et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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RNAi directed against members of the eIF3 protein complex does not affect Cyclin E expression but does affect Cyclin E-associated kinase activity. (A) Western blot for Cyclin E expression in whole cell extracts from S2R+ cells treated with the indicated dsRNAs. (B) Kinase activity on histone H1 of Cyclin E immunoprecipitates from S2R+ cells treated with the indicated dsRNAs. (C) Kinase activity on histone H1 of Cyclin E immunoprecipitates from S2R+ cells treated with dsRNA targeting the indicated members of the COP9 signalosome, proteasome lid or eIF3 protein complex in combination with either dsRNA targeting GFP or Dacapo.