Table 7.
Age-related fold changes in genes involved in mitochondrial function
| Bone marrow | Epididymal | ||||
|---|---|---|---|---|---|
| Symbol | Entrez Gene Name | 14M | 18M | 14M | 18M |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 1.51 | 1.38 | 1.27 | 1.23 |
| GLRX2 | glutaredoxin 2 | 1.36 | 1.79 | -1.05 | 1.38 |
| GPX4 | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 1.08 | 1.30 | -1.12 | -1.11 |
| MAOB | monoamine oxidase B | -1.23 | -1.39 | -1.06 | 1.31 |
| MT-ND4L | NADH dehydrogenase, subunit 4L (complex I) | -1.25 | -1.63 | -1.22 | -1.17 |
| NDUFA4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa | 1.11 | 1.81 | -1.21 | 1.00 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5 kDa | -1.72 | -1.69 | -1.15 | 1.12 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa | -1.46 | -1.68 | -1.07 | 1.04 |
| NDUFA12 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | -1.58 | -1.71 | -1.11 | 1.09 |
| NDUFA13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | -1.05 | -1.33 | -1.26 | -1.30 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | -1.26 | -1.38 | 1.50 | 1.05 |
| NDUFA9 (includes EG:4704) | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa | 1.11 | 1.77 | -1.46 | 1.10 |
| NDUFAF1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 | 1.18 | 1.87 | -1.41 | 1.42 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa | -1.31 | -1.40 | -1.35 | 1.09 |
| NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 kDa | -1.46 | -1.38 | -1.18 | 1.01 |
| NDUFB11 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa | -1.58 | -1.38 | -1.18 | -1.13 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase) | 1.29 | 2.22 | -1.21 | 1.67 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18 kDa (NADH-coenzyme Q reductase) | -1.22 | -1.39 | -1.03 | 1.48 |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase) | -1.53 | -1.51 | -1.16 | -1.08 |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase) | -1.37 | -1.52 | 1.14 | 1.46 |
| NDUFS6 (includes EG:4726) | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase) | 1.01 | 1.68 | -1.08 | 1.29 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa | -1.54 | -1.31 | -1.27 | 1.26 |
| NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10 kDa | -1.24 | -1.38 | -1.11 | -1.12 |
| PDHA1 (includes EG:5160) | pyruvate dehydrogenase (lipoamide) alpha 1 | 1.62 | 1.85 | -1.20 | 1.45 |
| PRDX3 | peroxiredoxin 3 | 1.19 | 2.39 | -1.42 | 1.19 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 1.31 | 1.51 | -1.35 | 1.06 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -1.25 | -1.31 | -1.35 | 1.10 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -1.08 | 1.67 | -1.16 | -3.22 |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 1.20 | 1.49 | -1.68 | -1.05 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -1.14 | -1.32 | -1.27 | 1.24 |
The list includes the mitochondrial genes that change with age in bone marrow and epididymal adipocytes. The set of regulated genes was selected on the basis of their expression in adipose cells according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.