Table 2. Meta-analysis of the association of SULT1A1 R213H polymorphism and colorectal cancer.* .
| Polymorphism | Study | Sample size | No. of Studies | Test of association | Test of heterogeneity | ||||||
| Case | Control | OR (95%CI) | Z | P-value | Model | χ2 | P-value | I2(%) | |||
| H vs R | Overall | 7098 | 11220 | 12 | 1.04(0.94–1.16) | 0.75 | 0.46 | R | 25.00 | 0.009 | 56.0 |
| HWE | 5716 | 9100 | 9 | 1.06(0.95–1.19) | 1.01 | 0.31 | R | 16.13 | 0.04 | 50.4 | |
| Caucasian | 6734 | 10334 | 10 | 1.02(0.92–1.15) | 0.41 | 0.68 | R | 22.83 | 0.007 | 60.6 | |
| HR+HH vs RR | Overall | 3319 | 5070 | 11 | 1.01(0.92–1.11) | 0.24 | 0.81 | F | 8,53 | 0.58 | 0.0 |
| HWE | 2858 | 4550 | 9 | 1.03(0.93–1.13) | 0.58 | 0.56 | F | 5.31 | 0.72 | 0.0 | |
| Caucasian | 3137 | 4627 | 9 | 0.99(0.91–1.09) | 0.12 | 0.90 | F | 5.53 | 0.70 | 0.0 | |
| HH vs RR+HR | Overall | 3319 | 5070 | 11 | 1.01(0.74–1.38) | 0.07 | 0.95 | R | 37.81 | <0.0001 | 73.6 |
| HWE | 2858 | 4550 | 9 | 1.10(0.78–1.56) | 0.57 | 0.57 | R | 32.46 | <0.0001 | 75.4 | |
| Caucasian | 3137 | 4627 | 9 | 1.01(0.73–1.39) | 0.04 | 0.97 | R | 37.34 | <0.0001 | 78.6 | |
| HH vs RR | Overall | 1945 | 2999 | 11 | 1.00(0.77–1.31) | 0.03 | 0.98 | R | 25.00 | 0.005 | 60.0 |
| HWE | 1648 | 2666 | 9 | 1.09(0.83–1.44) | 0.62 | 0.53 | R | 19.24 | 0.01 | 58.4 | |
| Caucasian | 1809 | 2641 | 9 | 0.99(0.75–1.31) | 0.07 | 0.94 | R | 24.55 | 0.002 | 67.4 | |
| HR vs RR | Overall | 2948 | 4482 | 11 | 1.01(0.92–1.11) | 0.18 | 0.86 | F | 10.75 | 0.38 | 6.9 |
| HWE | 2528 | 4028 | 9 | 1.02(0.92–1.13) | 0.32 | 0.75 | F | 9.68 | 0.29 | 17.3 | |
| Caucasian | 2771 | 4051 | 9 | 0.99(0.90–1.09) | 0.19 | 0.85 | F | 7.68 | 0.46 | 0.0 | |
*SULT1A1: sulfotransferase 1A1; vs: versus; R: random effect model; F: fixed effect model; HWE: Hardy-Weinberg equilibrium.