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. 2011 Jun 13;6(6):e20823. doi: 10.1371/journal.pone.0020823

Table 1. HY Reassortants: Gene Constellations and Fold Increase in HA Titer.

Reassortants Wild Type Virus HA Titer* [FI]** Gene Constellation of HY Reassortants Gene Ratio
(hy reassortant HA/wt HA) PB2 PB1 PA HA NP NA M NS (hy donor∶wt virus)
H1N1 (hy donor PR8 was used for X-53, X-53a; hy donor X-31b was used for X-127, X-139; hy donor NYMC X-157 was used for the remaining H1N1 reassortants)
X-53 A/New Jersey/11/1976 512/16 [32] P WT P WT P WT P P 5∶3
X53aa A/New Jersey/11/1976 8192/16 [512] P WT P WT P WT P P 5∶3
X-127a A/Beijing/262/1995 1024/256 [4] P WT P WT P WT P P 5∶3
X-139 A/New Caledonia/20/1999 512/128 [4] P WT P WT WT WT P P 4∶4
NYMC X-163 A/St. Petersburg/8/2006 2048/32 [64] P P P WT P WT P P 6∶2
NYMC X-163A A/St. Petersburg/8/2006 2048/32 [64] P P P WT P WT P P 6∶2
NYMC X-163B A/St. Petersburg/8/2006 1024/32 [32] P P P WT P WT P P 6∶2
NYMC X-173 A/South Dakota/06/2007 4096/128 [32] P P P WT P WT P P 6∶2
NYMC X-173A A/South Dakota/06/2007 4096/128 [32] P P P WT P WT P P 6∶2
NYMC X-173B A/South Dakota/06/2007 4096/128 [32] P P P WT P WT P P 6∶2
NYMC X-173C A/South Dakota/06/2007 4096/128 [32] P P P WT P WT P P 6∶2
NYMC X-177 A/Hong Kong/1870/2008 2048/256 [8] P P P WT P WT P P 6∶2
NYMC X-177A A/Hong Kong/1870/2008 4096/256 [16] P P P WT P WT P P 6∶2
NYMC X-177B A/Hong Kong/1870/2008 2048/256 [8] P P P WT P WT P P 6∶2
NYMC X-179 A/California/07/2009 4096/64 [64] P WT P WT P WT P P 5∶3
NYMC X-179Ab A/California/07/2009 2048/64 [32] P WT P WT P WT P P 5∶3
NYMC X-181b A/California/07/2009 4096/64 [64] P WT P WT P WT P P 5∶3
NYMC X-181A A/California/07/2009 4096/64 [64] P WT P WT P WT P P 5∶3
NYMC X-181B A/California/07/2009 2048/64 [32] P WT P WT P WT P P 5∶3
H3N2 (hy donor PR8 virus was used in the reassortment of the H3N2 viruses)
X-117a A/Beijing/32/1992 4096/512 [8] P P P WT P WT P P 6∶2
X-121a A/Shangdong/9/1993 512/128 [4] P P P WT P WT P P 6∶2
X-123 A/Johannesburg/33/1994 2048/64 [32] P P P WT P WT P P 6∶2
X-137 A/Moscow/10/1999 512/32 [16] P P P WT P WT P P 6∶2
X-141 A/Panama/2007/1999 2048/64 [32] P P P WT P WT P P 6∶2
X-143 A/Ulan Ude/01/2000 2048/256 [8] P P P WT P WT P P 6∶2
X-145 A/California/32/1999 512/32 [16] P WT P WT P WT WT P 4∶4
NYMC X-147a A/Wyoming/03/2003 1024/16 [64] P P P WT P WT P P 6∶2
NYMC X-149 A/Wyoming/03/2003 256/16 [16] WT WT WT WT P WT P P 3∶5
NYMC X-151 A/Fujian/445/2003 2048/256 [8] WT P P WT WT WT P WT 3∶5
NYMC X-153 A/Texas/40/2003 1024/64 [16] P P P WT WT WT P P 5∶3
NYMC X-155 A/Wellington/01/2004 2048/64 [32] P P P WT P WT P P 6∶2
NYMC X-157a A/New York/55/2004 2048/64 [32] P P P WT P WT P P 6∶2
NYMC X-157A A/New York/55/2004 2048/64 [32] P WT P WT P WT P P 5∶3
NYMC X-157B A/New York/55/2004 1024/64 [16] P P P WT P WT P P 6∶2
NYMC X-157C A/New York/55/2004 1024/64 [16] P P P WT P WT P P 6∶2
NYMC X-157D A/New York/55/2004 2048/64 [32] P P P WT P WT P P 6∶2
NYMC X-157E A/New York/55/2004 128/64 [2] WT WT WT WT P WT WT WT 1∶7
NYMC X-159 A/Mississippi/05/2004 1024/64 [16] P P P WT P WT P WT 5∶3
NYMC X-161a A/Wisconsin/67/2005 512/64 [8] WT WT WT WT WT WT P WT 1∶7
NYMC X-161Ba A/Wisconsin/67/2005 1024/64 [16] P P P WT P WT P P 6∶2
NYMC X-165 A/Nepal/921/2006 2048/128 [16] P WT P WT P WT P P 5∶3
NYMC X-167 A/Wisconsin/03/2007 256/16 [16] P WT P WT P WT P P 5∶3
NYMC X-169 A/Brisbane/09/2006 2048/16 [128] P P P WT P WT P P 6∶2
NYMC X-171 A/Brisbane/10/2007 1024/128 [8] WT WT WT WT WT WT P P 2∶6
NYMC X-171A A/Brisbane/10/2007 256/128 [2] P WT P WT P WT P WT 4∶4
NYMC X-171B A/Brisbane/10/2007 512/128 [4] P P P WT P WT P P 6∶2
NYMC X-171C A/Brisbane/10/2007 1024/128 [8] P P P WT WT WT P P 5∶3
NYMC X-171D A/Brisbane/10/2007 1024/128 [8] P P P WT WT WT P P 5∶3
NYMC X-175A A/Uruguay/716/2007 512/128 [4] P WT P WT P WT P P 5∶3
NYMC X-175Ca A/Uruguay/716/2007 2048/128 [16] P P P WT P WT P P 6∶2
NYMC X-183 A/Wisconsin/15/2009 1024/16 [64] P P P WT P WT P P 6∶2
NYMC X-185 A/Guangdong-Luohu/1256/2009 512/64 [8] P P P WT P WT P P 6∶2
NYMC X-187a A/Victoria/210/2009 1024/32 [32] P P P WT P WT P P 6∶2
NYMC X-187A A/Victoria/210/2009 1024/32 [32] P P P WT P WT P P 6∶2
NYMC X-189 A/Hong Kong/26560/2009 512/64 [8] P P P WT P WT P P 6∶2
NYMC X-191 A/Philippines/219/2009 1024/128 [8] P P P WT P WT P P 6∶2
NYMC X-197 A/Brisbane/11/2010 512/32 [16] P WT P WT P WT P P 5∶3

*HA Titer is given as reciprocal of viral dilution at titration end point.

**[FI]: fold increase in HA titer over wt parent virus.

a

Used in seasonal influenza vaccine production.

b

Used in 2009 H1N1pdm vaccine production.

P: hy donor virus A/PR/8/1934 gene. WT: wild type virus gene.