Table 2.

Showing the Isoforms of MT on Tumorgenesis

S.NO	CANCER	ISOFORMS	ROLE
1	Breast Cancer	MT-1 A,E,F,X, H,G, MT-3, MT-2A.	1) MT-1E: Alternative processes that replace the function of estrogen i;e breast cancer tumorgenesis. 2) MT-3: Poor prognosis for patients with breast cancer.
			3) MT-2A: Detected in breast tissue is positively correlated with cell proliferation and histological grade. 4) MT-1F: It found to influence histological differentiation in invasive breast cancer.
2	Renal Cancer	MT-1A, MT-1G, MT-IX, MT-3.	1) MT-3: Normal kidney & also in renal cell carcinoma, cancerous bladder tissues,(which was absent in normal bladder tissues)prostatic adenocarcinoma.. 2) MT-IX:Bladder cancer.
3	Prostate Cancer	MT-1A, MT-1E, MT-1X, MT-2A, MT-1, MT-2.	1) MT-IX:Advanced prostate cancer. 2) MT-1, MT-2: proliferative activity of breast, colon & prostate human cancer.
4	Papillary Thyroid Cancer	MT-1, MT-2.	Thyroid Cancer cells (KAT5 cells) + Calcium elevated ERK1/2 → 8 functional MT-1&MT2 induced By cd → MT expression+ Decrease in G0, G1 phase, Increase in G2-M phase → Novel pathway for Functional MT expression.