TABLE 4.
POLYMORPHONUCLEAR NEUTROPHIL RESPONSES TO 6.6-HOUR EXPOSURE TO CLEAN AIR AND 0.06 PPM OZONE IN HEALTHY YOUNG ADULTS
| All Subjects | Males | Females | GSTM1-p | GSTM1-n | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (n = 24) |
(n = 11) |
(n = 13) |
(n = 12) |
(n = 12) |
||||||
| Mean (± SEM) | 95% CI | Mean (± SEM) | 95% CI | Mean (± SEM) | 95% CI | Mean (± SEM) | 95% CI | Mean (± SEM) | 95% CI | |
| % Polymorphonuclear neutrophils | ||||||||||
| CA | 38.3 (3.7) | 31.1, 45.6 | 33.4 (5.3) | 23.0, 43.8 | 42.4 (5.1) | 32.4, 52.4 | 34.7 (5.6) | 23.7, 45.7 | 41.9 (4.8) | 32.5, 51.3 |
| Ozone | 54.0 (4.6) | 45.0, 63.0 | 57.6 (6.4) | 45.1, 70.1 | 50.9 (6.6) | 38.0, 63.8 | 46.1 (6.7) | 33.0, 59.2 | 61.9 (5.5) | 51.1, 72.7 |
| Ozone-CA | 15.7 (3.1)* | 9.6, 21.8 | 24.2 (4.3)* | 15.8, 32.6 | 8.5 (3.7)* | 0.79, 16.2 | 11.3 (4.5)* | 2.3, 20.3 | 20.0 (4.6)* | 11.0, 29.0 |
| Total cell count | ||||||||||
| CA | 5.05 × 106 (0.82) | 4.08 × 106 (0.98) | 5.86 × 106 (1.26) | 3.97 × 106 (0.90) | 6.13 × 106 (1.34) | |||||
| Ozone | 6.93 × 106 (1.52) | 9.42 × 106 (3.03) | 4.83 × 106 (0.96) | 5.58 × 106 (2.23) | 8.28 × 106 (2.10) | |||||
Definition of abbreviations: CA = clean air; CI = confidence interval; GSTM1-n = glutathione S-transferase mu 1 null; GSTM1-p = glutathione S-transferase mu 1 positive; PMN = polymorphonuclear neutrophils.
%PMN indicates polymorphonuclear neutrophils as % of total cell counts. SEM of total cell count is for the base number of 106.
*
P < 0.05.