Figure 3.

Targeting of NCOR2 by miR-10. (a) Reduction of NCOR2 mRNA and (b) protein following transfection of SK-N-BE with miR-10a, miR-10b or miR-10a/b. (c) Cotransfections of SK-N-BE cells with luciferase reporter construct (Psi/miR-10) containing NCOR2 3′-UTR and either NC oligonucleotide or miR-10a, miR-10b or miR-10a/b. Similar cotransfections with these olignucleotides and a luciferase reporter construct with a mutated miR-10 target site (Psi/miR-10mut) abrogated the reduction in luciferase activity