Table 2.

Downstream effectors of FcγR-mediated phagocytosis or chemotaxis in macrophage.

		Phagocytosis	Chemotaxis	References
Serine/Threonine Kinase	PAK	✓	✓	[202–204]
	MEK/ERK	✓	✓	[10, 32, 205–208]
	PKC	✓	✓	[70, 72, 73, 209–211]
Lipid Kinases	PI3K	✓	✓	[64, 79–81, 83, 88, 94, 133, 212]
	PI4P-5Kα, γ	✓	?	[62, 63, 213, 214]
	PLC	✓	?	[66–69]
	PLD	✓	✓	[215–218]
Lipid Phosphatases	PTEN	✓	✓	[219, 220]
	SHIP	✓	✓	[100, 102, 103, 124, 221]
Ubiquitin Ligase	c-Cbl	✓	✓	[15, 110, 222–224]
GTPases	Cdc42	✓	✓	[38–40, 56, 139, 141]
	Rac	✓	✓	[38–40, 138, 225]
	RhoA	?	✓	[41, 226]
	Arf1	✓	?	[64]
	Arf6	✓	✓	[60, 61, 64, 227, 228]
	Rab11, 5, 7	✓	?	[229–231]
	Dynamin	✓	✓	[84, 232, 233]
GEFs	Vav	✓	✓	[44–46, 124, 234, 235]
	DOCK180	✓	?	[48]
GAP	p190RhoGAP	?	✓	[164, 236]
Actin regulatory proteins	WASP/N-WASP	✓	✓	[45, 52, 53, 56, 142, 143, 151, 237, 238]
	WAVE2	X	✓	[59, 140]
	Paxillin	✓	✓	[127, 167, 196, 197, 239, 240]
	Cortactin	?	✓	[127, 241]
	LIMK	✓	✓	[211, 242, 243]
	Cofilin	✓	✓	[211, 242, 243]
	Arp2/3	✓	✓	[55, 244, 245]
Adaptor proteins	LAT	✓	?	[246, 247]
	Grb2	✓	✓	[218, 248–251]
	Gab2	✓	✓	[249, 252]
	Nck	✓	?	[45, 250]
	Crk	✓	✓	[48, 166, 250, 253]
Contractile proteins	Myosin II	✓	✓	[83, 94, 177, 254, 255]
	Myosin X, Va	✓	?	[92, 93]
	MLCK	✓	✓	[94, 255]

FOOTNOTES : ✓, Downstream effector.; ?, Unknown or controversial