Table 1.

Conserved sequence/structure motifs and functionally important regions of PV RdRp

Subdomain	Conserved structural/functional regions	Sequencea	Function
Fingers	G	113 STSAGYPY 120	Template bindingb
	F	153 PLVTYVKDELRSKTKVEQGKSRLIEA 178	NTP and template binding
	I	107 LEALDL 112	Template binding
	II	184 SVAMRMAFGNLYAAFHK 200	Template binding
Palm	A	229 LFAFDYTGYDAS 240	2′-OH of NTP and metal B binding
	B	293 TSIFNSMINNLIIRTLLLKT 312	Base of NTP and template binding
	C	323 MIAYGDDVIAS 333	Primer and metal A binding and catalysis
	D	338 VDASLLAQSGKDYGLTMTPADKSAT 362	Triphosphate of NTP binding and catalysis
	E	363 FETVTWENVTFLKRFFRA 380	Nascent RNA 3′-end binding
Thumb	III	405 KDPRNTQDHVRSLCLL 420	Nascent RNA duplex binding

^aThe residues shown in boldface are completely conserved among RdRps; those residues representing signatures of the conserved sequence motifs are shown in boldface and underlined.¹⁸

^bThe identification of residues' functions was based on the crystal structure of the RdRp–RNA–NTP complex of FMDV RdRp (PDB code 1WNE).¹⁹