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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Exp Neurol. 2011 May 6;230(2):227–239. doi: 10.1016/j.expneurol.2011.04.021

Fig. 5.

Fig. 5

EPO or CEPO protect against white matter injury in H/I/L. UCL with hypoxia and LPS injection caused selective injury in both the ipsilateral and contralateral white matter. (A) At 96 h after insult, MBP depletion was observed in cerebral white matter of PVL mouse pups. (B, C) After injury, EPO or CEPO treatment attenuated MBP loss in both ipsilateral and contralateral sides. (D) After H/I/L, O1 expression was reduced in the white matter of both hemispheres. (E, F) Treatment with EPO or CEPO reduced O1 depletion. (G) Quantification revealed significant protection of MBP cells after treatment with EPO or CEPO in the contralateral white matter (*p<0.05) and ipsilateral white matter (**p<0.01). (H) Both EPO and CEPO treatments increased O1 expression in the injured white matter (*p<0.05). Scale bar, 10 µm.