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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Neurobiol Dis. 2011 May 14;43(2):516–525. doi: 10.1016/j.nbd.2011.05.005

Figure 7.

Figure 7

Hypoxia induces proteasome-dependent presynaptic silencing. A. FM1-43fx/vGluT-1 correspondence assay. Green = FM1-43fx. Red = vGluT-1. Red puncta with no green overlap are mute synapses, while yellow indicates overlap and active synapses. A 2 hr preconditioning period with or without MG-132 (3 μM) was followed by 2 hr hypoxic insult (or sham) with immediately subsequent FM1-43fx assay. B. Summary of experiments depicted in panel A showing the percentage of active synapses after hypoxic insult with and without MG-132 co-incubation (n=25 fields from 5 independent experiments). Asterisk denotes p < 0.05 compared with hypoxia alone (Bonferroni corrected t-tests). Comparisons of control versus MG-132, control versus hypoxia plus MG-132, and MG-132 versus hypoxia plus MG-132 showed no differences.

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