Table 1.
Cohort characteristics. Disability data were obtained within 30 days of the MRI scan.
| all MS | CIS | RRMS | SPMS | PPMS | healthy | |
|---|---|---|---|---|---|---|
| # participants (% women) | 115 (68%) | 4 (75%) | 77 (74%) | 18 (61%) | 16 (44%) | 42 (71%) |
| mean age, years (SD; range) | 43 (11; 20-68) | 30 (9; 22-39) | 39 (10; 20-62) | 52 (8; 29-63) | 52 (7; 39-68) | 34 (10; 22-63) |
| mean disease duration, years (SD; range) | 9 (7; 0-30) | 0 (0; 0-0) | 7 (6; 0-25) | 17 (8; 2-30) | 8 (6; 1-19) | |
| on disease-modifying treatment | 73% | 0% | 89% | 59% | 33% | |
| relapse within 30 days prior to scan | 5% | 50% | 4% | 6% | 0% | |
| median EDSS (range) | 3 (0-6.5) | 1.5 (0-3) | 2 (0-6) | 6 (2-6.5) | 5.25 (2.5-6.5) | |
| mean MSSS (SD) | 4.5 (2.6) | 1.5 (1.7) | 3.8 (2.4) | 5.6 (2.1) | 7.0 (1.7) | |
| mean MSFC (SD) | 0.0 (0.6) | -0.3 (.4) | -0.1 (.4) | 0.3 (.9) | 0.3 (.6) | |
| mean PASAT-3 (SD) | 48 (11) | 44 (12) | 48 (11) | 46 (11) | 47 (13) | |
| mean 9HPT, sec (SD) | 25 (14) | 19 (2) | 23 (12) | 31 (22) | 31 (15) | |
| mean 25FTW, sec (SD) | 5.9 (4.3) | 4.6 (0.3) | 4.7 (1.6) | 8.9 (5.9) | 8.8 (7.7) |