Table 3.
Regression results for disability scores vs. MD in the corpus callosum. Values indicate the fraction of variance in disability score that is explained by each combination of MRI index and regression model. Model 1 considers only age, sex, and whole-brain MRI index; Model 2 adds the average tract-specific MRI index; and Model 3 uses penalized functional regression to account for spatial variation in the tract-specific MRI index.
| Disability Score | Model 1 | Model 2 | Model 3 | % improvement | |
|---|---|---|---|---|---|
| 3 vs. 1 | 3 vs. 2 | ||||
| EDSS | 0.36 | 0.36 | 0.37 | 3% | 3% |
| MSSS | 0.14 | 0.16 | 0.18 | 29% | 13% |
| MSFC | 0.10 | 0.14 | 0.16 | 60% | 14% |
| PASAT-3 | 0.08 | 0.19 | 0.21 | 163% | 11% |
| 9HPT | 0.13 | 0.13 | 0.14 | 8% | 8% |
| 25FTW | 0.16 | 0.16 | 0.17 | 6% | 6% |