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. Author manuscript; available in PMC: 2012 Jun 20.
Published in final edited form as: Vaccine. 2011 May 5;29(28):4638–4645. doi: 10.1016/j.vaccine.2011.04.045

Figure 6. Plasma botulinum toxin level after challenge of vaccinated mice.

Figure 6

Groups of mice (three mice per group) were immunized and boosted with RABV-HC50/A, RABV-HC50/A and alum, recombinant HC50/A and alum or left untreated. The mice were challenged one week after the boost by the intravenous route with 5 ng botulinum neurotoxin (103 mouse LD50), and blood was collected by retro-orbital bleeding at the indicated time points after the challenge. The figure shows levels of botulinum toxin detectable in plasma pools from mice vaccinated with RABV-HC50/A,■--■; RABV-HC50/A+alum◆--◆; HC50/A and alum, ▲--▲; and untreated mice, ●--●.