Figure 4.

Overexpression of Nxfz3 or Kermit inhibits endogenous eye formation. (a) Uninjected embryo at stage 41. (b and c) Nxfz3-injected embryos at stage 41 showing a reduced (b) or absent eye (c) on the injected side (white arrow). (d) Section through an embryo with a missing eye, showing the loss of normal eye structure on the injected side with only residual disorganized pigment remaining (black arrow). The tissue derived from the injected blastomere is marked with β-galactosidase (sky blue). (e) Uninjected embryo at stage 43. (f) Kermit-injected embryo at stage 43 showing a reduced eye on the injected side (arrow).