Fig. 9.

Whole brain F₂-isoprostanes were significantly increased in Sepp1^−/− mice relative to Sepp1^+/+. Brains from Sepp1^−/− and Sepp1^+/+ mice fed a diet containing 1 mg selenium/kg for 28 days and then switched to a selenium-deficient diet (day 0) for 18 days were collected and cerebral F₂-isoprostanes measured. Values represent means (SE) and statistical comparisons were performed using a one-tailed t-test (* p < 0.05, n > 3 per group).