Table 1.
Patient characteristics
| Never Smokers | Former Smokers | Current Smokers | ||
|---|---|---|---|---|
| Characteristic | (N=530) (%) | (N=230) (%) | (N=85) (%) | p-value |
| Age (years) | <0.0005 | |||
| median (IQR) | 50 (38–59) | 58 (51–63) | 46 (32–57) | |
| Male | 302 (57) | 138 (60) | 47 (55) | 0.67 |
| Caucasian race | 456 (89) | 205 (92) | 77 (93) | 0.81 |
| Pack-years | ||||
| median (IQR) | - | 10 (4–20) | 15 (6–30) | 0.05 |
| Donor HLA status | 0.68 | |||
| related/matched | 191 (36) | 86 (37) | 30 (35) | |
| related/mismatched | 27 (5) | 13 (6) | 8 (9) | |
| unrelated/matched | 204 (39) | 80 (35) | 27 (32) | |
| unrelated/mismatched | 107 (20) | 51 (22) | 20 (24) | |
| Disease risk | 0.35 | |||
| Low | 41 (8) | 11 (5) | 7 (8) | |
| Intermediate | 299 (56) | 146 (63) | 48 (57) | |
| High | 190 (36) | 73 (32) | 30 (35) | |
| Conditioning regimen | 0.001 | |||
| Non-myeloablative | 204 (38) | 123 (53) | 25 (29) | |
| Myeloablative | ||||
| Non-TBI | 170 (32) | 55 (24) | 37 (44) | |
| TBI ≤ 12 Gy | 132 (25) | 47 (20) | 19 (22) | |
| TBI > 12 Gy | 20 (4) | 5 (2) | 3 (3) | |
| Stem cell source | 0.75 | |||
| Bone marrow | 75 (14) | 30 (13) | 14 (16) | |
| PBSC | 420 (79) | 190 (83) | 67 (79) | |
| BM, PBSC | 3 (1) | 0 | 0 | |
| Cord | 32 (6) | 10 (4) | 4 (5) | |
| CMV (recipient/donor) | 0.27 | |||
| neg/neg | 149 (30) | 67 (30) | 27 (33) | |
| neg/pos | 57 (12) | 19 (9) | 4 (5) | |
| pos/neg | 140 (28) | 77 (35) | 27 (33) | |
| pos/pos | 151 (30) | 56 (26) | 23 (29) | |
| Acute GVHD | 73 (14) | 27 (12) | 11 (13) | 0.74 |
| Chronic GVHD | 218 (52) | 93 (54) | 22 (32) | 0.005 |
| Bronchoscopy performed | 99 (19) | 52 (23) | 17 (20) | 0.46 |